Hi Everyone, Sharing with you all what is Calcifying Epithelial Odontogenic Tumor. Study from this for your exams, score high and leave your comments below if these notes help you
OUTLINE
- OTHER NAMES
- DEFINITION
- ORIGIN
- CLINICAL FEATURES
- RADIOGRAPHIC FEATURES
- HISTOPATHOLOGIC FEATURES
- TREATMENT & PROGNOSIS
OTHER NAMES
- PINDBORG TUMOR
- Also called as CEOT (Calcifying Epithelial Odontogenic Tumor)
WHY CALLED A PINDBORG TUMOR????
First described in 1956 by the late Dr Jens J Pindborg, thus the name Pindborg Tumor
DEFINITION
The calcifying epithelial odontogenic tumor (CEOT) is a locally invasive epithelial odontogenic neoplasm, characterized by the presence of amyloid material that may become calcified.
- Benign
- Odontogenic neoplasm exclusively epithelial in origin
- Uncommon (CEOT accounts for approximately 1% of all odontogenic tumors )
ORIGIN
- The definite etiology of this neoplasm still remains enigmatic. Many authorities believe that it is derived either from:-
CLINICAL FEATURES
- AGE – Middle-age, patients between 20 and 60 years of age, with a mean around 40 years
- SEX – No gender predilection, equal frequency in both males & females
- SITE – More common in MANDIBLE
- Mandible :Maxilla = 2 : 1 i.e. about two thirds of cases found in mandible, most often in the posterior areas (prevalence in the molar region is three times that in the bicuspid region)
- Thus, most common site is MANDIBULAR MOLAR REGION
- Although Pindborg tumor shares clinical features with ameloblastoma as to site and age predilection, it is significantly less frequent in incidence
- Asymptomatic
- Painless swelling
- Slow growing expansile mass of the jaws
- 52% of reported cases associated with an unerupted or impacted tooth
- Most cases of CEOT are Intraosseous i.e. within bone
- Approximately 6% arise in extraosseous locations(i.e. outside bone). PERIPHERAL/EXTRAOSSEOUS lesions usually occur in the anterior gingiva. The extraosseous lesion is histologically identical with the intraosseous one
RADIGRAPHIC FEATURES
Considerable radiographic variation:-
- Diffuse or a well-circumscribed unilocular radiolucent area
- Or there may appear to be a combined pattern of radiolucency and radiopacity with many small, irregular bony trabeculae traversing the radiolucent area in many directions, producing a multilocular or honeycomb pattern.
- Scattered flecks of calcification throughout the radiolucency have given rise to the descriptive term of a ‘DRIVEN SNOW’ appearance.
- Some instances, the lesion is totally radiolucent and is in association with an impacted tooth, usually a mandibular third molar.
- Computed tomography and magnetic resonance imaging provide useful information in the diagnosis and treatment of CEOT
HISTOPATHOLOGIC FEATURES
- The tumor consists of a fibrous stroma with islands and sheets of polyhedral epithelial cells with:-
- abundant eosinophilic finely granular cytoplasm
- sharply defined cell borders
- well developed intercellular bridges
- The nuclei are:-
- frequently pleomorphic with giant nuclei and multinucleation being quite common
- mitotic figures rare
- Abundant, eosinophilic, homogeneous, hyaline material (AMYLOID) is present within or around the sheets of tumor cells. It is often calcified in the form of concentric rings (LIESEGANG RING CALCIFICATION)
- (liesegang ring means concentric rings) In CEOT calcification occurs in such rings
- One of the characteristic microscopic features of CEOT is the presence of a homogeneous, eosinophilic substance considered to be AMYLOID. This is so because it stains in a fashion similar to amyloid:-
- Positive staining with Congo red (shows apple green birefringence when subjected to polarized light)
- Stains metachromatically with crystal violet
- fluoresces under ultraviolet light with thioflavin T
- Some tumors are amyloid-rich, while others demonstrate epithelial-predominance.
- Clear-cell variant of CEOT – When Clear cells i.e. cells with clear cytoplasm within the epithelial nests are predominant
TREATMENT & PROGNOSIS
- CEOT is a locally invasive tumor
- An overall recurrence rate of about 14% has been noted
- Complete excision of the tumor with a border of normal bone should be curative, but recurrence follows incomplete excision
- Long-term follow-up is recommended
REFERENCES
- World Health Organization Classification of Tumors
- Shafer’s Textbook Of Oral Pathology
- Neville – Oral & Maxillofacial Pathology
- Image-Wikipedia & Wikimedia Commons